Isis combines ease of use and a functionality meeting the requirements of even the most demanding research and routine applications. With the help of automatic exposure time adjustment, and with the support of most of the common motorized microscopes, it reliably acquires fluorescence images with up to 12 color channels. For image processing, Isis provides a variety of tools to enhance, edit, annotate, archive, measure, and print the images. The optimized user interface guarantees rapid results in research and routine. Isis can be either installed as a stand-alone system, or it can be seamlessly integrated into Ikaros karyotyping stations, the Metafer slide scanning workstation, or any multi-user workplace with networked stations. Options for color karyotyping, comparative genomic hybridization (CGH), multicolor FISH (mFISH), multicolor fluorochrome banding (mBAND), and for automatic telomere measurement are available.